This report presents the characteristics of police reported road traffic crashes and the resulting casualties which occurred in Ghana during the period 1991-2020, and in particular for the year 2020. In-depth analysis of the crash data for the year 2020 has been carried out and compared with the previous year, 2019, as well as the year 2001 when the first National Road Safety Strategy (NRSS I) was developed and then also with the year 2011 when the UN Decade of Action on road safety began. Average proportions have also been established for the most recent three years (i.e., 2018 - 2020) for the distribution of casualties and fatalities by age, road user class, road environment and gender to reflect the current crash situations. The statistics further highlight the long term trends in fatality rates, regional distribution of crashes and casualties, road user groups at risk and some key attributes of the crash such as month, day and hour of occurrence as well as the weather, lighting and road conditions prevailing at the time of the crashes. The report further focuses on areas that need to be targeted in order to achieve reduction in road traffic crashes in Ghana.